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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described by their focus on practical aspects of study design that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results is also essential. However excessive heterogeneity could result in problems with the design of the trial.
Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, offers an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic experience in gambling and a wide variety of betting options via virtual. The company also has several game shows that make online gambling exciting and interactive. Some of these shows are hosted live, while others feature famous personalities in the industry.
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Pragmatic Play is a new player in the online casino market however, it has established itself by offering mobile-friendly slots. Their games are optimised for mobile devices and run on HTML5 technology. They're also certified by trusted gaming authorities to ensure transparency and fairness. This is a great indicator for players because it indicates that the games have been thoroughly tested and verified in order to guarantee the randomness and unbiased results of every game.
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Legality
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can be used to determine the cause-effect relationship of an intervention and its results. However, they shouldn't be used to substitute for explanatory trials.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study that includes recruitment, design, delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary care settings.